Parallel and high sensitive photonic crystal cavity assisted read-out for DNA-chips
| 作者： | Ferruccio Pisanello, Luigi Martiradonna, Pier Paolo Pompa, Tiziana Stomeo, Antonio Qualtieri, Giuseppe Vecchio, Stefania Sabella, Massimo De Vittorio |
| 作者单位： |
1National Nanotechnology Laboratory of CNR/INFM, ISUFI – Università del Salento, via per Arnesano, Lecce 73100, Italy 2Laboratoire Kastler Brossel, CNRS UMR8552, Universitè Pierre et Marie Curie, Ecole Normale Supérieure, 4 place Jussieu, 75252 Paris Cedex 05, France 3Italian Institute of Technology (IIT), Center for Bio-Molecular Nanotechnology, Via Barsanti, 1 – 73010 Arnesano, Lecce, Italy |
| 刊名： | Microelectronic Engineering, 2009, Vol.87 (5), pp.747-749 |
| 来源数据库： | Elsevier Journal |
| DOI： | 10.1016/j.mee.2009.11.158 |
| 关键词： | Photonic crystal nanocavity; Bio-chip; Silicon nitride membrane; |
| 英文摘要： | Abstract(#br)In this work we propose a new technological approach aimed at improving the performances of DNA-chips in terms of detection sensitivity, signal-to-noise ratio and parallel analyses (spatial and spectral). It is based on the efficient enhancement of markers fluorescence through the insertion of photonic crystal nanocavities (PhC) in DNA-chips, thus giving higher sensitivity and allowing detection of small amounts of target biomolecules in the investigated solution. Moreover, this strategy univocally associates a specific emission wavelength to a specific nanocavity (and to the bio-probe immobilized on it), therefore allowing to infer the presence of a determined element in the solution by a simple spectral analysis of the optical response of the read-out region. This... |
