Vitamin D receptor (VDR) non-synonymous single nucleotide polymorphisms (nsSNPs) affect the calcitriol drug response - A theoretical insight
作者: Karthikeyan MuthusamySelvaraman Nagamani
作者单位: 1Department of Bioinformatics, Alagappa University, Karaikudi, 630 004, India
刊名: Journal of Molecular Graphics and Modelling, 2018, Vol.81 , pp.14-24
来源数据库: Elsevier Journal
DOI: 10.1016/j.jmgm.2018.02.004
关键词: VDRSNPDrug effectMolecular dynamics simulations
原始语种摘要: Abstract(#br)Pharmacogenetics and pharmacogenomics have become presumptive with advancements in next-generation sequencing technology. In complex diseases, distinguishing the feasibility of pathogenic and neutral disease-causing variants is a time consuming and expensive process. Recent drug research and development processes mainly rely on the relationship between the genotype and phenotype through Single nucleotide polymorphisms (SNPs). The SNPs play an indispensable role in elucidating the individual's vulnerability to disease and drug response. The understanding of the interplay between these leads to the establishment of personalized medicine. In order to address this issue, we developed a computational pipeline of vitamin D receptor (VDR) for SNP centered study by application of...
全文获取路径: Elsevier  (合作)
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影响因子:2.325 (2012)

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关键词翻译
关键词翻译
  • calcitriol 骨化三醇
  • synonymous 同意义的
  • VDR Validated Data Record
  • nucleotide 核苷酸
  • insight 识别力
  • receptor 接受体
  • affect 给影响
  • theoretical 理论的
  • response 响应
  • single 单独的