Comparison of Second-Phase Insulin Secretion Derived from Standard and Modified Low-Dose Graded Glucose Infusion Tests
作者: Jiunn-Diann LinChung-Ze WuWen-Hao TangFeng-Chih KuoDee PeiYao-Jen LiangYen-Lin Chen
作者单位: 1Division of Endocrinology, Department of Internal Medicine, Shuang Ho Hospital, Taipei Medical University, Taipei, Taiwan
2Division of Endocrinology and Metabolism, Department of Internal Medicine, Tri-Service General Hospital, Taipei, Taiwan
3Department of Internal Medicine, Cardinal Tien Hospital, School of Medicine, Fu-Jen Catholic University, New Taipei City, Taiwan
4Associate Dean of College of Science and Engineering, Director of Graduate Institute of Applied Science and Engineering, Department and Institute of Life-Science, Fu-Jen Catholic University, New Taipei, Taiwan
5Department of Pathology, Cardinal Tien Hospital, School of Medicine, Fu-Jen Catholic University, New Taipei City, Taiwan
刊名: Canadian Journal of Diabetes, 2016
来源数据库: Elsevier Journal
DOI: 10.1016/j.jcjd.2016.03.007
关键词: low-dose graded glucose infusion testmodified low-dose graded glucose infusion testsecond-phase insulin secretion
原始语种摘要: Abstract(#br)Objectives(#br)Insulin secretion has 2 phases, first-phase and second-phase insulin secretion (SPIS). The purpose of our study was to validate the SPIS derived from the modified low-dose graded glucose infusion test (MLDGGI) by using the standard SPIS derived from the low-dose graded glucose infusion test (LDGGI).(#br)Methods(#br)Fourteen participants were enrolled. The participants underwent the LDGGI for 200 minutes and MLDGGI for 60 minutes. The LDGGI was administered using the standard Polonsky method, which entails 5 40-minute stages of glucose infusion (1, 4, 8, 6 and 24 mg/kg/min). The slopes of the insulin levels vs. the glucose levels obtained during the test were regarded as SPIS (SPIS-I). Furthermore, deconvolution was performed, and slopes of the insulin secretion...
全文获取路径: Elsevier  (合作)
影响因子:0.458 (2012)

  • pendant 下垂的
  • glucose 葡萄糖
  • rapport 关系
  • perfusion 灌注
  • convolution 褶积
  • minutes 会谈记要
  • tapes 缀锦蛤属
  • relation 关系
  • standard 标准
  • phase 相位