Outcome of antiepileptic drug treatment of 1282 patients with epilepsy, their pharmacovigilance reports and concomitant medication on CNS in an East-Hungarian adult database
作者: László HorváthKlára FeketeSándor MártonIstván Fekete
作者单位: 1University of Debrecen, Faculty of Pharmacy, Department of Pharmaceutical Surveillance and Economy, Nagyerdei krt. 98., Debrecen, Hungary
2University of Debrecen, Faculty of Medicine, Department of Neurology, Móricz Zs. krt. 22., Debrecen, Hungary
3University of Debrecen, Faculty of Art, Institute of Political Science and Sociology, Egyetem tér 1., Debrecen, Hungary
刊名: Journal of the Neurological Sciences, 2016, Vol.369 , pp.220-226
来源数据库: Elsevier Journal
DOI: 10.1016/j.jns.2016.08.039
关键词: EpilepsyDatabaseAntiepileptic drug treatmentSeizure freedomAdverse drug reactionPharmacovigilance
英文摘要: Abstract(#br)Objective(#br)The aim of this study was to determine the outcome of antiepileptic drug (AED) treatment based on seizure freedom, pharmacovigilance reports and effects of concomitant medication on the central nervous system (CNS) of adult epileptic patients registered in the East-Hungarian Epilepsy Database.(#br)Methods(#br)Prospective cross-sectional database was compiled from outpatient files between 1992 and 2011.(#br)Results(#br)The majority of 1282 treated patients were on monotherapy 894 patients (70%), 286 (22%) on bitherapy and 102 (8%) on polytherapy. Of all treated patients, seizure freedom was achieved by 603 (47%). Among the seizure free patients 464 (77%) were on monotherapy, 115 (19%) on bitherapy and only 24 (4%) on polytherapy. The overall rate of adverse drug...
全文获取路径: Elsevier  (合作)
影响因子:2.243 (2012)

  • antiepileptic 镇痫剂
  • epilepsy 癫痫
  • adult 成体
  • treatment 处理
  • medication 药疗法
  • database 资料库
  • concomitant 伴行的
  • freedom 自由
  • reaction 反酌
  • reports 判例汇编