Hydrogen sulfide in the regulation of insulin secretion and insulin sensitivity: Implications for the pathogenesis and treatment of diabetes mellitus
作者: Jerzy BełtowskiGrażyna WójcickaAnna Jamroz-Wiśniewska
作者单位: 1Department of Pathophysiology, Medical University, Lublin, Poland
2Department of Neurology, Medical University, Lublin, Poland
刊名: Biochemical Pharmacology, 2018, Vol.149 , pp.60-76
来源数据库: Elsevier Journal
DOI: 10.1016/j.bcp.2018.01.004
关键词: Hydrogen sulfideCystathionine β-synthaseCystathionine-lyasePancreatic β cellsInsulin sensitivityInsulin resistanceDiabetes mellitusObesity
原始语种摘要: Abstract(#br)Insulin secretion and sensitivity play an essential role in maintaining normal glucose level and their abnormalities result in diabetes mellitus. H 2 S-synthesizing enzymes, CBS and/or CSE, are expressed in insulin-secreting pancreatic β cells and H 2 S inhibits insulin secretion by activating ATP-sensitive K + channels. In addition, H 2 S has been reported to have either pro- or antiapoptotic effects on β cells. Studies in the animal models suggest that excess of H 2 S in pancreatic islets may contribute to both type 1 and type 2 diabetes. H 2 S has also been demonstrated to regulate insulin sensitivity. In the liver, H 2 S stimulates gluconeogenesis and glycogenolysis and inhibits glucose utilization and glycogen storage. Its effect on insulin-stimulated glucose uptake in...
全文获取路径: Elsevier  (合作)
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影响因子:4.576 (2012)

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关键词翻译
关键词翻译
  • insulin 胰岛素
  • diabetes 糖尿病
  • secretion 分泌
  • sensitivity 灵敏度
  • sulfide 硫化物
  • synthase 合酶
  • pathogenesis 发病机理
  • lyase 裂合酶
  • regulation 
  • cells 麻风细胞