Summary of expression of SPARC protein in cutaneous vascular neoplasms and mimickers
作者: Shakuntala H. MauzoDenái R. MiltonVictor G. PrietoCarlos A. Torres-CabalaWei-Lien WangNitin ChakravartiPriyadharsini NagarajanMichael T. TetzlaffJonathan L. CurryDoina IvanRobert E. BrownPhyu P. Aung
作者单位: 1Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA
2Department of Biostatistics, The University of Texas MD Anderson Cancer Center, Houston, TX, USA
3Department of Pathology, The University of Texas Health Science Center, Houston, TX, USA
刊名: Annals of Diagnostic Pathology, 2018, Vol.34 , pp.151-154
来源数据库: Elsevier Journal
DOI: 10.1016/j.anndiagpath.2018.03.005
关键词: SPARC expressionImmunohistochemical studyAFXKaposi SarcomaMelanomaCutaneous angiosarcoma
原始语种摘要: Abstract(#br)Background(#br)Serum protein acidic and rich in cysteine (SPARC) is a matricellular glycoprotein, which regulates cell proliferation and facilitates intracellular transport of albumin bound particles including chemotherapeutic agents such as Nab-paclitaxel/ABI-007. Therefore the presence of SPARC may achieve higher intra-tumoral drug concentration with lower dosage and thus reduce systemic side-effects. Several trials of ABI-007, in melanoma, show promising clinical activity.(#br)Design(#br)Fifty-four cases of dermal based neoplasms were retrieved including 24 angiosarcomas (AS), 10 hemangiomas, 9 nodular melanomas, 4 Kaposi sarcomas (KS), 3 leiomyosarcomas (LMS), 3 atypical fibroxanthomas (AFX) and 1 spindle cell squamous cell carcinoma (SSCC). SPARC immunohistochemistry...
全文获取路径: Elsevier  (合作)
影响因子:0.975 (2012)

  • expression 表示
  • SPARC Scalable Processor ARChitecture
  • protein 蛋白质
  • angiosarcoma 血管肉瘤
  • vascular 维管的
  • neoplasms 新生物
  • cutaneous 皮肤的
  • study 学习