Characterizing parathyroid carcinomas and atypical neoplasms based on the expression of programmed death-ligand 1 expression and the presence of tumor-infiltrating lymphocytes and macrophages
作者: Angelica Silva-FigueroaPamela VillalobosMichelle D. WilliamsRoland L. BassettCallisia N. ClarkeJeffrey E. LeeNaifa L. BusaidyNancy D. Perrier
作者单位: 1Department of Surgical Oncology, University of Texas M. D. Anderson Cancer Center, Houston, Texas
2Department of Translational Molecular Pathology, University of Texas M. D. Anderson Cancer Center, Houston, Texas
3Department of Pathology, University of Texas M. D. Anderson Cancer Center, Houston, Texas
4Department of Biostatistics, University of Texas M. D. Anderson Cancer Center, Houston, Texas
5Division of Surgical Oncology, Medical College of Wisconsin, Milwaukee, Wisconsin
6Department of Endocrine Neoplasia and Hormonal Disorders, University of Texas M. D. Anderson Cancer Center, Houston, Texas
刊名: Surgery, 2018
来源数据库: Elsevier Journal
DOI: 10.1016/j.surg.2018.06.013
原始语种摘要: Abstract(#br)Background(#br)Four distinct tumor microenvironments have been proposed based on the expression of programmed death-ligand 1 and the presence of tumor-infiltrating lymphocytes: immunotype I (adaptive resistance, tumor-infiltrating lymphocytes+ and programmed death-ligand 1+); immunotype II (immunologic ignorance, tumor-infiltrating lymphocytes– and programmed death-ligand 1–); immunotype III (intrinsic induction; tumor-infiltrating lymphocytes– and programmed death-ligand 1+); and immunotype IV (tolerance, tumor-infiltrating lymphocytes+ and programmed death-ligand 1–). These subtypes may predict tumor response to immunotherapy. We hypothesized that parathyroid neoplasms may have tumor immunogenic expression that can later be used to guide treatment.(#br)Methods(#br)We...
全文获取路径: Elsevier  (合作)
分享到:
来源刊物:
影响因子:3.373 (2012)

×
关键词翻译
关键词翻译
  • programmed 制订计划了的编制程序了的按程序工作的
  • infiltrating 浸润的
  • parathyroid 甲状旁膀切除
  • atypical 非典型的
  • neoplasms 新生物
  • expression 表示
  • ligand 配合体
  • tumor 肿胀
  • density 密度
  • presence 存在