Glatiramer acetate positively influences spinal motoneuron survival and synaptic plasticity after ventral root avulsion
作者: Juliana Milani ScorisaRenata Graciele ZanonCamila Marques FreriaAlexandre Leite Rodrigues de Oliveira
作者单位: 1Dept. of Anatomy - Institute of Biology, University of Campinas (UNICAMP), Campinas, SP, Brazil
刊名: Neuroscience Letters, 2008, Vol.451 (1), pp.34-39
来源数据库: Elsevier Journal
DOI: 10.1016/j.neulet.2008.12.017
关键词: Ventral root avulsionSpinal cordSynapse eliminationMotoneuronImmunomodulatorGlatiramer acetate
原始语种摘要: Abstract(#br)Avulsion of ventral roots induces degeneration of most axotomized motoneurons. At present there are no effective strategies to prevent such neuronal loss and to preserve the affected spinal circuits. Interestingly, changes in the spinal cord network also occur during the course of the experimental model of multiple sclerosis (experimental autoimmune encephalomyelitis—EAE). Glatiramer acetate (GA) significantly reduces the seriousness of the symptoms during the exacerbation of EAE. However, little is known about its effects on motoneurons. In the present study, we investigated whether GA has an influence on synapse plasticity and glial reaction after ventral root avulsion (VRA). Lewis rats were subjected to the avulsion of lumbar ventral roots and treated with GA. The animals...
全文获取路径: Elsevier  (合作)
影响因子:2.026 (2012)

  • avulsion 撕脱
  • acetate 醋酸盐
  • motoneuron 运动神经元
  • spinal 脊柱的
  • ventral 腹的
  • synaptic 突触的
  • plasticity 可塑性
  • cords 灯芯绒裤
  • glial 神经胶质的
  • experimental 实验的