Differential regulation of FGF-2 in neurons and reactive astrocytes of axotomized rat hypoglossal nucleus. A possible therapeutic target for neuroprotection in peripheral nerve pathology
作者: Gabriela Pintar de OliveiraTatiana DuoblesPatrícia CastelucciGerson Chadi
作者单位: 1Neuroregeneration Center, Department of Neurology, University of São Paulo School of Medicine, University of São Paulo, Av. Dr. Arnaldo, 455 2nd floor, room 2119, 01246-903 São Paulo, Brazil
2Department of Anatomy, Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil
刊名: Acta Histochemica, 2009, Vol.112 (6), pp.604-617
来源数据库: Elsevier Journal
DOI: 10.1016/j.acthis.2009.06.008
关键词: Fibroblast growth factor-2Nerve lesionParacrine actionNeuroplasticityAstrocytePeripheral nervous systemRat
原始语种摘要: Summary(#br)Despite the favorable treatment of cranial nerve neuropathology in adulthood, some cases are resistant to therapy leading to permanent functional impairments. In many cases, suitable treatment is problematic as the therapeutic target remains unknown. Basic fibroblast growth factor (bFGF, FGF-2) is involved in neuronal maintenance and wound repair following nervous system lesions. It is one of few neurotrophic molecules acting in autocrine, paracrine and intracrine fashions depending upon specific circumstances. Peripheral cranial somatic motor neurons, i.e. hypoglossal (XII) neurons, may offer a unique opportunity to study cellular FGF-2 mechanisms as the molecule is present in the cytoplasm of neurons and in the nuclei of astrocytes of the central nervous system. FGF-2 may...
全文获取路径: Elsevier  (合作)
影响因子:1.608 (2012)

  • nerve 叶脉
  • therapeutic 治疗的
  • hypoglossal 舌下的
  • nucleus 晶核
  • peripheral 周边的
  • adult 成体
  • neurotrophic 神经营养的
  • FGF 成纤维细胞生长因子
  • crush 轧碎
  • glial 神经胶质的