Polymers with distinctive anticancer mechanism that kills MDR cancer cells and inhibits tumor metastasis
作者: Guansheng ZhongChuan YangShaoqiong LiuYiran ZhengJye Yng TeoWeiyang LouChang BaoWei ChengJeremy P.K. TanShujun GaoNathaniel ParkShrinivas VenkataramanYuan HuangMin Han TanXiaojia WangJames L. HedrickWeimin FanYi Yan Yang
作者单位: 1Department of Thyroid and Breast Surgery, Zhejiang Provincial People's Hospital, People's Hospital of Hangzhou Medical College, Hangzhou, Zhejiang Province, China
2Institute of Bioengineering and Nanotechnology, 31 Biopolis Way, The Nanos, 138669, Singapore
3Program of Innovative Therapeutics, First Affiliated Hospital, Zhejiang University, Hangzhou, 310003, China
4IBM Research-Almaden, 650 Harry Road, San Jose, CA 95120, United States
5Department of Medical Oncology, Zhejiang Cancer Hospital, Hangzhou, Zhejiang, 310022, China
刊名: Biomaterials, 2019
来源数据库: Elsevier Journal
DOI: 10.1016/j.biomaterials.2019.01.036
关键词: Functional polymersGuanidinium-functionalized polycarbonateAnticancerMultidrug resistanceTumor metastasis
英文摘要: Abstract(#br)Although mortality continues to decline over the past two decades, cancer is still a pervasive healthcare problem worldwide due to the increase in the number of cases, multidrug resistance (MDR) and metastasis. As a consequence of multidrug resistance, cancer treatment must rely on a host of chemotherapeutic agents and chemosensitizers to achieve remission. To overcome these problems, a series of biodegradable triblock copolymers of PEG, guanidinium-functionalized polycarbonate and polylactide (PEG-PGC x -PDLA y ) is designed as chemotherapeutic agents. These copolymers self-assemble into micellar nanoparticles, and are highly effective against various cancer cell lines including human breast cancer (BCap37), liver cancer (HepG2), lung cancer (A549) and epidermoid carcinoma...
全文获取路径: Elsevier  (合作)
影响因子:7.604 (2012)

  • anticancer 抗癌的
  • distinctive 区别的
  • metastasis 同质蜕变
  • tumor 肿胀
  • cells 麻风细胞
  • mechanism 机构