The effects of methylmercury on motor activity are sex- and age-dependent, and modulated by genetic deletion of adenosine receptors and caffeine administration
作者: Olga BjörklundJohan KahlströmPeter SalmiSven Ove ÖgrenMarie VahterJiang-Fan ChenBertil B. FredholmElisabetta Daré
作者单位: 1Department of Physiology and Pharmacology, Karolinska Institutet, S-171 77 Stockholm, Sweden
2Department of Neuroscience, Karolinska Institutet, S-171 77 Stockholm, Sweden
3Institute of Environmental Medicine, Karolinska Institutet, S-171 77 Stockholm, Sweden
4Department of Neurology, Boston University School of Medicine, Boston, MA 02118, United States
刊名: Toxicology, 2007, Vol.241 (3), pp.119-133
来源数据库: Elsevier Journal
DOI: 10.1016/j.tox.2007.08.092
关键词: MethylmercuryCaffeineAdenosine receptorsKnock-out micePsychostimulantsBehavioral analysis
原始语种摘要: Abstract(#br)Adenosine and its receptors are, as part of the brain stress response, potential targets for neuroprotective drugs. We have investigated if the adenosine receptor system affects the developmental neurotoxicity caused by the fish pollutant methylmercury (MeHg). Behavioral outcomes of low dose perinatal MeHg exposure were studied in mice where the A 1 and A 2A adenosine receptors were either partially blocked by caffeine treatment or eliminated by genetic modification (A 1 R and A 2A R knock-out mice). From gestational day 7 to day 7 of lactation dams were administered doses that mimic human intake via normal diet, i.e. 1μM MeHg and/or 0.3g/l caffeine in the drinking water. This exposure to MeHg resulted in a doubling of brain Hg levels in...
全文获取路径: Elsevier  (合作)
影响因子:4.017 (2012)

  • caffeine 咖啡碱
  • adenosine 腺苷
  • methylmercury 甲基汞
  • genetic 遗传的
  • inactivation 失活
  • postnatal 出生后的
  • lasting 持久
  • neurotoxicity 神经中毒性
  • dependent 从属的
  • exposure 暴露