Relevance to investigate different stages of pregnancy to highlight toxic effects of nanoparticles: The example of silica
作者: Antonio PietroiustiLucia VecchioneMaria Ada MalvindiCinzia AruMicol MassimianiAntonella CamaioniAndrea MagriniRoberta BernardiniStefania SabellaPier Paolo PompaLuisa Campagnolo
作者单位: 1Department of Biomedicine and Prevention, University of Rome Tor Vergata, Via Montpellier 1, Rome 00133, Italy
2Department of Physics, University of Calabria, Via P. Bucci, Cubo 31 C, Arcavacata di Rende, CS 87036, Italy
3Nanobiointeractions & Nanodiagnostics, Center for Biomolecular Nanotechnologies@UniLe, Istituto Italiano di Tecnologia, Via Barsanti, Arnesano, Lecce 73010, Italy
4Animal Technology Station, University of Rome “Tor Vergata”, Via Montpellier 1, Rome 00133, Italy
5Italian Institute of Technology, D3_Pharma Chemistry, Via Morego, Genova, GE 16146, Italy
6Nanobiointeractions & Nanodiagnostics, Istituto Italiano di Tecnologia, Via Morego, 30, Genova 16163, Italy
刊名: Toxicology and Applied Pharmacology, 2018, Vol.342 , pp.60-68
来源数据库: Elsevier Journal
DOI: 10.1016/j.taap.2018.01.026
关键词: NanoparticlesToxicityPregnancyPlacentaFetusSilica
原始语种摘要: Abstract(#br)Amorphous silica nanoparticles (SiO 2 NPs) have been recognized as safe nanomaterial, hence their use in biomedical applications has been explored. Data, however, suggest potential toxicity of SiO 2 NPs in pregnant individuals. However, no studies relating nanoparticle biokinetic/toxicity to the different gestational stages are currently available. In this respect, we have investigated the possible embryotoxic effects of three-size and two-surface functionalization SiO 2 NPs in mice. After intravenous administration of different concentrations at different stages of pregnancy, clinical and histopathological evaluations, performed close to parturition, did not show signs of maternal toxicity, nor effects on placental/fetal development, except for amino-functionalized 25 nm...
全文获取路径: Elsevier  (合作)
影响因子:3.975 (2012)

  • silica 硅土
  • nanoparticle 乳酸
  • pregnancy 妊娠
  • gestational 妊娠期的
  • administration 管理
  • different 不相同的
  • surface 
  • toxicity 毒性
  • biokinetic 生物动力学
  • covering 覆盖物