P43 Antioxidant and heart-protective effect of endogenous hydrogen sulfideon rats with streptozotocin-induced diabetes
作者: Wei GuoZhuijun WangMotao SunJuntao KanZumei LiuYizhun Zhu
作者单位: 1School of Pharmacy, Fudan University, Shanghai 201203, China
2Yong Loo Lin School of Medicine, Clinical Research Centre, National University of Singapore, Singapore 119074, Singapore
刊名: Nitric Oxide, 2012, Vol.27 , pp.S31-S31
来源数据库: Elsevier Journal
DOI: 10.1016/j.niox.2012.08.044
原始语种摘要: Numerous studies have shown that diabetic heart is characterized by compromised ventricular contraction and prolonged relaxation attributable to multiple causative factors especially oxidative stress. Hydrogen sulfide (H 2 S) has cardioprotective effects. This study was designed to investigate S-propargyl-cysteine (SPRC), an H 2 S donor, as well as its effect on the progression of heart-protective effectinStreptozotocin-Induced Diabetic Ratsand underlying mechanisms. Fifty male Sprague–Dawley Rats (5 groups, n =10) were grouped into the normal control, diabetic control and low, moderate, and high doses of SPRC-treated groups. Six weeks later, SPRC-treated rats showed a significant alleviation in the development of heart dysfunction in a dose-dependent...
全文获取路径: Elsevier  (合作)
影响因子:3.265 (2012)

  • streptozotocin 链脲佐菌素
  • diabetes 糖尿病
  • endogenous 内成的
  • effect 效应
  • induced 感应的
  • heart 心脏
  • protective 保护的
  • hydrogen