Hydrophobic poly (amino acid) modified PEI mediated delivery of rev-casp-3 for cancer therapy
作者: Chunling FuLin LinHengliang ShiDaxue ZhengWei WangShiqian GaoYifei ZhaoHuayu TianXiaojuan ZhuXuesi Chen
作者单位: 1Key Laboratory of Molecular Epigenetics of Ministry of Education, Institute of Cytology and Genetics, Northeast Normal University, Changchun, China
2Key Laboratory of Polymer Ecomaterials, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, China
刊名: Biomaterials, 2012, Vol.33 (18), pp.4589-4596
来源数据库: Elsevier Journal
DOI: 10.1016/j.biomaterials.2012.02.057
关键词: Amphiphilic cationic polymerPP80Rev-casp-3BiocompatibilityCancer therapy
原始语种摘要: Abstract(#br)Recent studies in amphiphilic cationic polymers have demonstrated their potential as gene carriers with high transfection efficiency and low cytotoxicity in the in vitro settings to deliver drug, siRNA and plasmid DNA. Yet their safety and efficacy in vivo remain to be a challenge, and require further investigation. In our previous work, PP80 was synthesized as a novel amphiphilic cationic polymer by grafting hydrophobic polyphenylalanine segment on PEI, which displayed higher transfection efficiency than PEI in a number of cell lines in vitro . Here, we reported the favorable biocompatibility displayed by PP80/pDNA complex both in vitro and in vivo . Furthermore, when therapeutic gene rev-casp-3 was conjugated to PP80 and administered intratumorally to a HeLa xenograft...
全文获取路径: Elsevier  (合作)
影响因子:7.604 (2012)

  • amino acid 氨酸
  • delivery 移交
  • cancer 癌症
  • therapy 治疗
  • modified 改进
  • rev 每分钟转数
  • poly