Association Between Angiotensin-Converting Enzyme Insertion/Deletion Polymorphisms and Frailty Among Chinese Older People
作者: Shanping ChenQiukui HaoMing YangJirong YueLi CaoGuanjian LiuChuan ZouXiang DingHongshan PuBirong Dong
作者单位: 1Center of Gerontology and Geriatrics, West China Hospital, Sichuan University, Chengdu, China
2Chinese Cochrane Center, West China Hospital, Sichuan University, Chengdu, China
3The Center of Coordination and Innovation for Aging Care and Health Promotion of Sichuan, Chengdu, China
刊名: Journal of the American Medical Directors Association, 2015, Vol.16 (5), pp.438.e1-438.e6
来源数据库: Elsevier Journal
DOI: 10.1016/j.jamda.2015.01.094
关键词: FrailtyACEgene polymorphismphysical functioninsertion/deletion
英文摘要: Abstract(#br)Objectives(#br)Frailty involves complex mechanisms of cumulative decline in several physiological systems and is associated with adverse events that are determined by genetic and environmental factors. It has been reported that angiotensin-converting enzyme (ACE) gene insertion/deletion (I/D) polymorphisms are associated with human performance. However, the relationships between ACE polymorphisms and frailty are poorly understood. Therefore, we used a Chinese community-dwelling cohort to examine these relationships.(#br)Design and setting(#br)This study is a part of the Comprehensive Geriatric Assessment and Health Care Service Study, which is a cross-sectional study being conducted in Southwest China.(#br)Participants and measurements(#br)The participants were grouped into...
全文获取路径: Elsevier  (合作)
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