Disparate effects of antidiabetic drugs on arterial contraction
作者: Jacob D. PeulerJohn A. MillerMahmoud BourghliHassan Y. ZammamEdward E. SoltisJames R. Sowers
作者单位: 1Department of Pharmacology, Midwestern University, Downers Grove, IL USA
2Department of Internal Medicine, Wayne State University and VAMC, Detroit, MI USA
3Division of Pharmacology, College of Pharmacy, University of Kentucky, Lexington, KY USA
刊名: Metabolism, 1997, Vol.46 (10), pp.1199-1205
来源数据库: Elsevier Journal
DOI: 10.1016/S0026-0495(97)90217-1
原始语种摘要: Abstract(#br)Type II diabetic patients and others with insulin resistance are at risk for development of hypertension characterized by elevated peripheral vascular resistance and loss of insulin's normal vasodilating activity. Oral antidiabetic drugs have recently been recognized to have disparate effects on arterial pressure in such patients and in related rodent models. Sulfonylureas (eg, glyburide), which stimulate insulin secretion, have been reported either to increase or not to affect arterial pressure, whereas nonsulfonylurea agents with insulin-sensitizing properties, the biguanide metformin and various thiazolidinediones (eg, pioglitazone), have been reported to decrease arterial pressure in humans and rodents. To help elucidate these disparate effects, we investigated these...
全文获取路径: Elsevier  (合作)
影响因子:3.096 (2012)