Biological adaptive control model: a mechanical analogue of multi-factorial bone density adaptation
作者: Peter L. DavidsonPeter D. MilburnBarry D. Wilson
作者单位: 1Injury Prevention Research Unit, Department of Preventive and Social Medicine, Dunedin School of Medicine, University of Otago, P.O. Box 913, Dunedin, New Zealand
2School of Physiotherapy, University of Otago, P.O. Box 56, Dunedin, New Zealand
3School of Physical Education, University of Otago, P.O. Box 56, Dunedin, New Zealand
刊名: Journal of Theoretical Biology, 2003, Vol.227 (2), pp.187-195
来源数据库: Elsevier Journal
DOI: 10.1016/j.jtbi.2003.10.012
关键词: Multi-factorial bone density adaptationDynamic systems analysisBiomechanicsNewtonian modelTransient tissue behaviour
原始语种摘要: Abstract(#br)The mechanism of how bone adapts to every day demands needs to be better understood to gain insight into situations in which the musculoskeletal system is perturbed. This paper offers a novel multi-factorial mathematical model of bone density adaptation which combines previous single-factor models in a single adaptation system as a means of gaining this insight. Unique aspects of the model include provision for interaction between factors and an estimation of the relative contribution of each factor. This interacting system is considered analogous to a Newtonian mechanical system and the governing response equation is derived as a linear version of the adaptation process. The transient solution to sudden environmental change is found to be exponential or oscillatory depending...
全文获取路径: Elsevier  (合作)
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影响因子:2.351 (2012)

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