Activated protein C analog with reduced anticoagulant activity improves functional recovery and reduces bleeding risk following controlled cortical impact
作者: Corey T. WalkerAndrew H. MarkyAnthony L. PetragliaTracy AliNienwen ChowBerislav V. Zlokovic
作者单位: 1Center for Neurodegenerative and Vascular Brain Disorders, University of Rochester Medical Center, Arthur Kornberg Medical Research Building, 601 Elmwood Ave, Box 670, Rochester, New York 14642, USA
2Department of Neurosurgery, University of Rochester Medical Center, Rochester, New York, USA
3ZZ Biotech, L.L.C., Rochester, NY, USA
刊名: Brain Research, 2010, Vol.1347 , pp.125-131
来源数据库: Elsevier Journal
DOI: 10.1016/j.brainres.2010.05.075
关键词: Activated protein C analogTraumatic brain injuryNeuroprotectionHemorrhage
原始语种摘要: Abstract(#br)The anticoagulant activated protein C (APC) protects neurons and vascular cells from injury through its direct cytoprotective effects that are independent of its anticoagulant action. Wild-type recombinant murine APC (wt-APC) exerts significant neuroprotection in mice if administered early after traumatic brain injury (TBI). Here, we compared efficacy and safety of a late therapy for TBI with wt-APC and 3K3A-APC, an APC analog with ∼80% reduced anticoagulant activity but normal cytoprotective activity, using a controlled cortical impact model of TBI. Mice received 0.8mg/kg intraperitoneally of recombinant murine 3K3A-APC, wt-APC or saline at 6, 12, 24 and 48h after injury. 3K3A-APC ( n =...
全文获取路径: Elsevier  (合作)
影响因子:2.879 (2012)