Alkylating agent methyl methanesulfonate (MMS) induces a wave of global protein hyperacetylation: Implications in cancer cell death
作者: Min-Young LeeMyoung-Ae KimHyun-Ju KimYoe-Sik BaeJoo-In ParkJong-Young KwakJay H. ChungJeanho Yun
作者单位: 1Department of Biochemistry, College of Medicine, Dong-A University, 3-1, Dongdaeshin-Dong, Seo-Gu, Busan 602-714, South Korea
2Laboratory of Biochemical Genetics, NHLBI, NIH, 10 Center Drive, Bethesda, MD 20892, USA
刊名: Biochemical and Biophysical Research Communications, 2007, Vol.360 (2), pp.483-489
来源数据库: Elsevier Journal
DOI: 10.1016/j.bbrc.2007.06.084
关键词: Protein acetylationMethyl methanesulfonateCell deathHDAC inhibitors
英文摘要: Abstract(#br)Protein acetylation modification has been implicated in many cellular processes but the direct evidence for the involvement of protein acetylation in signal transduction is very limited. In the present study, we found that an alkylating agent methyl methanesulfonate (MMS) induces a robust and reversible hyperacetylation of both cytoplasmic and nuclear proteins during the early phase of the cellular response to MMS. Notably, the acetylation level upon MMS treatment was strongly correlated with the susceptibility of cancer cells, and the enhancement of MMS-induced acetylation by histone deacetylase (HDAC) inhibitors was shown to increase the cellular susceptibility. These results suggest protein acetylation is important for the cell death signal transduction pathway and...
全文获取路径: Elsevier  (合作)