High-Resolution Human/Goat Comparative Map of the Goat Polled/Intersex Syndrome (PIS): The Human Homologue Is Contained in a Human YAC from HSA3q23
作者: Daniel VaimanLaurent SchiblerAnne Oustry-VaimanEric PailhouxTom GoldammerMilena StevanovicJean-Pierre FuretManfred SchwerinCorinne CotinotMarc FellousEdmond P. Cribiu
作者单位: 1Laboratoire de Génétique biochimique et de Cytogénétique, Departement de Génétique Animale, INRA, 78352, Jouy-en-Josas, France
2Laboratoire de Biologie cellulaire et moléculaire, INRA, 78350, Jouy-en-Josas, France
3Department of Molecular Biology, Research Institute for the Biology of Farm Animals, Dummersdorf, Germany
4Laboratoire d'Immunogénétique Humaine, Institut Pasteur, 26 rue du Dr. Roux, 75015, Paris, France
5IMGGE, P.O. Box 794, 11001, Belgrade, Serbia
刊名: Genomics, 1999, Vol.56 (1), pp.31-39
来源数据库: Elsevier Journal
DOI: 10.1006/geno.1998.5691
原始语种摘要: Abstract(#br)The genetic and cytogenetic map around the chromosome 1 region shown to be linked with polledness and intersexuality (PIS) in the domestic goat ( Capra hircus ) was refined. For this purpose, a goat BAC library was systematically screened with primers from human coding sequences, scraped chromosome 1 DNA, bovine microsatellites from the region, and BAC ends. All the BACs ( n = 30) were mapped by fluorescence in situ hybridization (FISH) on goat chromosome 1q41–q45. The genetic mapping of 30 new goat polymorphic markers, isolated from these BACs, made it possible to reduce the PIS interval to a region of less than 1 cM on goat chromosome 1q43. The PIS locus is now located between the two genes ATP1B and COP, which both map to 3q23 in humans. Genetic, cytogenetic, and...
全文获取路径: Elsevier  (合作)
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影响因子:3.01 (2012)

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