The relationship between transepidermal water loss and skin permeability
作者: Marta MachadoTeresa M. SalgadoJonathan HadgraftMajella E. Lane
作者单位: 1Department of Pharmaceutics, The School of Pharmacy, University of London, 29-39 Brunswick Square, London WC1N 1AX, United Kingdom
刊名: International Journal of Pharmaceutics, 2009, Vol.384 (1), pp.73-77
来源数据库: Elsevier Journal
DOI: 10.1016/j.ijpharm.2009.09.044
关键词: SkinStratum corneumCorneocyte sizeTransepidermal water lossPathlength
原始语种摘要: Abstract(#br)Transepidermal water loss (TEWL) is a measure of the steady-state water vapour flux crossing the skin to the external environment and it has been used extensively to characterise skin barrier function. We have previously hypothesised that in vivo TEWL is directly related to the reciprocal of the diffusional permeation pathlength through the stratum corneum (SC). The aim of the present paper is to validate experimentally this hypothesis. Ninety volunteers were recruited and TEWL and corneocyte surface areas were measured for six anatomic sites. The number of cell layers in the SC was calculated for each anatomic site in order to estimate the geometric pathlength for water efflux. Significant anatomic site variability was found for both TEWL and corneocyte surface area which...
全文获取路径: Elsevier  (合作)
影响因子:3.458 (2012)