A case-control study of polymorphisms in xenobiotic and arsenic metabolism genes and arsenic-related bladder cancer in New Hampshire
作者: Corina LesseurDiane Gilbert-DiamondAngeline S. AndrewRebecca M. EkstromZhongze LiKarl T. KelseyCarmen J. MarsitMargaret R. Karagas
作者单位: 1Department of Community and Family Medicine, Section of Biostatistics and Epidemiology, Dartmouth Medical School, 1 Medical Center Drive, 7927 Rubin Building, Lebanon, NH 03756, USA
2Department of Pharmacology and Toxicology, Dartmouth Medical School, 7650 Remsen, Hanover, NH 03755, USA
3Biostatistics Shared Resource, Norris Cotton Cancer Center, Dartmouth Medical School, 1 Medical Center Drive, Lebanon, NH 03756, USA
4Department of Community Health, Epidemiology Section, Brown University, Box G-E5, Providence, RI 02912, USA
刊名: Toxicology Letters, 2012, Vol.210 (1), pp.100-106
来源数据库: Elsevier Journal
DOI: 10.1016/j.toxlet.2012.01.015
关键词: ArsenicGenetic polymorphismsBladder cancerCase-control studyGene-environment interaction
原始语种摘要: Abstract(#br)Arsenic is associated with bladder cancer risk even at low exposure levels. Genetic variation in enzymes involved in xenobiotic and arsenic metabolism may modulate individual susceptibility to arsenic-related bladder cancer. Through a population-based case-control study in NH (832 cases and 1191 controls), we investigated gene-environment interactions between arsenic metabolic gene polymorphisms and arsenic exposure in relation to bladder cancer risk. Toenail arsenic concentrations were used to classify subjects into low and high exposure groups. Single nucleotide polymorphisms (SNPs) in GSTP1 , GSTO2 , GSTZ1 , AQP3 , AS3MT and the deletion status of GSTM1 and GSTT1 were determined. We found evidence of genotype-arsenic interactions in the high exposure group; GSTP1 Ile105Val...
全文获取路径: Elsevier  (合作)
影响因子:3.145 (2012)