Detection of complement factor B in the cerebrospinal fluid of patients with cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy disease using two-dimensional gel electrophoresis and mass spectrometry
作者: Mustafa ÜnlüRobert P.J. de LangeRajith de SilvaRaj KalariaDavid St. Clair
作者单位: 1Proteomics Facility, Polwarth Building, University of Aberdeen, Foresterhill, Aberdeen, AB25 2ZD, UK
2Department of Mental Health, Polwarth Building, University of Aberdeen, Foresterhill, Aberdeen, AB25 2ZD, UK
3Institute of Neurological Sciences, Southern General Hospital, Glasgow, G51 4TF, UK
4Institute for Health of the Elderly, Newcastle General Hospital, Westgate Road, Newcastle-upon-Tyne, NE4 6BE, UK
刊名: Neuroscience Letters, 2000, Vol.282 (3), pp.149-152
来源数据库: Elsevier Journal
DOI: 10.1016/S0304-3940(00)00875-2
关键词: Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathyCerebrospinal fluidTwo-dimensional gel electrophoresisMass spectrometryComplement factor B
原始语种摘要: Abstract(#br)Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is a hereditary condition with onset in mid-adulthood and is associated with mutations in the Notch-3 gene. (Joutel, A., Corepechot, C., Ducros, A., Vahedi, K., Chabriat, H., Mouton, P., Alamowitch, S., Domenda, V., Cecilion, M., Marechal, J., Vayssiere, C., Cruaud, C., Cabanis, E.A., Ruchoux, M.M., Weissenvach, J., Bach, J.F., Bousser, M.G. and Tournier-Lasserve, E., Notch3 mutations in CADASIL, a hereditary adult-onset condition causing stroke and dementia. Nature, 383 (1996) 707–710) Ultrastructural examination of the pathology of the cerebral infarcts reveals deposits in the vascular smooth muscle cells of the small arteries of the brain, but there is no obvious indication...
全文获取路径: Elsevier  (合作)
分享到:
来源刊物:
影响因子:2.026 (2012)

×