Adjuvanticity of native and detoxified adenylate cyclase toxin of Bordetella pertussis towards co-administered antigens
作者: Julia MacDonald-FyallDorothy XingMichael CorbelSusan BaillieRoger PartonJohn Coote
作者单位: 1Division of Infection and Immunity, Institute of Biomedical and Life Sciences, Joseph Black Building, University of Glasgow, Glasgow G12 8QQ, UK
2National Institute for Biological Standards and Control, South Mimms, Herts EN6 3QG, UK
刊名: Vaccine, 2004, Vol.22 (31), pp.4270-4281
来源数据库: Elsevier Journal
DOI: 10.1016/j.vaccine.2004.04.033
关键词: Adenylate cyclase toxinBordetella pertussisAdjuvant
原始语种摘要: Abstract(#br)The cell-invasive adenylate cyclase toxin (CyaA) of Bordetella pertussis was shown to be highly antigenic in mice, stimulating serum anti-CyaA IgG antibody responses which were able to neutralise the cytotoxic effect of CyaA on J774.2 macrophage-like cells. The effect of co-administration to mice of the fully functional CyaA toxin or a toxin lacking adenylate cyclase enzymic activity (CyaA * ) with other antigens from B. pertussis , namely pertussis toxin (PT) or pertussis toxoid (PTd), filamentous haemagglutinin (FHA) and pertactin (PRN), was investigated. CyaA * enhanced the serum IgG antibody responses to each of these antigens whereas, with CyaA, only anti-PRN antibody titres showed a modest increase. Peritoneal macrophages and spleen cells, collected at 2 weeks...
全文获取路径: Elsevier  (合作)
影响因子:3.492 (2012)