ERK1/2 and p38-MAPK signalling pathways, through MSK1, are involved in NF-κB transactivation during oxidative stress in skeletal myoblasts
作者: Eirini KefaloyianniCatherine GaitanakiIsidoros Beis
作者单位: 1Department of Animal and Human Physiology, School of Biology, Faculty of Sciences, University of Athens, Panepistimioupolis, Athens 157 84, Greece
刊名: Cellular Signalling, 2006, Vol.18 (12), pp.2238-2251
来源数据库: Elsevier Journal
DOI: 10.1016/j.cellsig.2006.05.004
关键词: NF-κBMAPKSignal transductionMyoblastsMSK1Oxidative stress
原始语种摘要: Abstract(#br)Skeletal muscle is highly adapted to respond to oxidative imbalances, since it is continuously subjected to an increased production of reactive oxygen species (ROS) during exercise. Oxidative stress, however, has been associated with skeletal muscle atrophy and damage in many diseases. In this study, we examined whether MAPK and NF-κB pathways participate in the response of skeletal myoblasts to oxidative stress, and whether there is a cross talk between these pathways. H 2 O 2 induced a strong activation of ERKs, JNKs and p38-MAPK in a time- and dose-dependent profile. ERK and JNK activation by H 2 O 2 , but not that of p38-MAPK, was mediated by Src kinase and, at least in part, by EGFR. H 2 O 2 also stimulated a mild translocation of NF-κB to the nucleus, as well as a...
全文获取路径: Elsevier  (合作)
影响因子:4.304 (2012)