Parallel and high sensitive photonic crystal cavity assisted read-out for DNA-chips
作者: Ferruccio PisanelloLuigi MartiradonnaPier Paolo PompaTiziana StomeoAntonio QualtieriGiuseppe VecchioStefania SabellaMassimo De Vittorio
作者单位: 1National Nanotechnology Laboratory of CNR/INFM, ISUFI – Università del Salento, via per Arnesano, Lecce 73100, Italy
2Laboratoire Kastler Brossel, CNRS UMR8552, Universitè Pierre et Marie Curie, Ecole Normale Supérieure, 4 place Jussieu, 75252 Paris Cedex 05, France
3Italian Institute of Technology (IIT), Center for Bio-Molecular Nanotechnology, Via Barsanti, 1 – 73010 Arnesano, Lecce, Italy
刊名: Microelectronic Engineering, 2009, Vol.87 (5), pp.747-749
来源数据库: Elsevier Journal
DOI: 10.1016/j.mee.2009.11.158
关键词: Photonic crystal nanocavityBio-chipSilicon nitride membrane
英文摘要: Abstract(#br)In this work we propose a new technological approach aimed at improving the performances of DNA-chips in terms of detection sensitivity, signal-to-noise ratio and parallel analyses (spatial and spectral). It is based on the efficient enhancement of markers fluorescence through the insertion of photonic crystal nanocavities (PhC) in DNA-chips, thus giving higher sensitivity and allowing detection of small amounts of target biomolecules in the investigated solution. Moreover, this strategy univocally associates a specific emission wavelength to a specific nanocavity (and to the bio-probe immobilized on it), therefore allowing to infer the presence of a determined element in the solution by a simple spectral analysis of the optical response of the read-out region. This...
全文获取路径: Elsevier  (合作)
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影响因子:1.224 (2012)

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