Virtual screening on potential neuraminidase inhibitors of influenza A virus H1N1
作者: Salam Pradeep SinghDhrubajyoti GogoiRajib Lochan BezbaruahManab Jyoti BordoloiNabin Chandra Barua
作者单位: 1Bioinformatics Infrastructure Facility, Biotechnology Division, CSIR-North-East Institute of Science & Technology, Jorhat 785006, Assam, India
2CSIR-Natural Products Chemistry Division, North-East Institute of Science & Technology, Jorhat 785006, Assam, India
刊名: Drug Invention Today, 2013, Vol.5 (3), pp.241-245
来源数据库: Elsevier Journal
DOI: 10.1016/j.dit.2013.06.005
关键词: H1N1ZanamivirNeuraminidaseIn silicoMolecular docking
英文摘要: Abstract(#br)Background(#br)Influenza A virus H1N1 causes human influenza (flu) in 2009. Some strains of H1N1 are endemic in humans and cause a small fraction of all influenza-like illness and a small fraction of all seasonal influenza. Zanamivir which blocks the function of the viral neuraminidase protein of influenza A virus H1N1, thus preventing the virus from reproducing by budding from the host cell has been reported for having resistance against the virus. The neuraminidase enzyme is a glycoside hydrolase enzyme which is found on the surface. It enables the virus to be released from the host cell and cleave sialic acid groups from glycoproteins and is required for influenza virus replication. The World Health Organization declared the H1N1 influenza pandemic on August 10,...
全文获取路径: Elsevier  (合作)