Remodeling of ion channel expression may contribute to electrophysiological consequences caused by methamphetamine in vitro and in vivo
作者: Yi-Hong QuKa-Pui LeungDong-Fang QiaoDong-Ri LiChao LiuXia YueHui-Jun Wang
作者单位: 1Department of Forensic Medicine, Southern Medical University, No.1838, Guangzhou 510515, Guangdong Province, PR China
2Department of Legal Medicine, Osaka City University Medical School, Asahi-machi 1-4-3, Abeno, 545-8585 Osaka, Japan
3Guangzhou Forensic Science Institute, Guangzhou 510030, Guangdong Province, PR China
刊名: Biochemical and Biophysical Research Communications, 2014, Vol.443 (2), pp.441-446
来源数据库: Elsevier Journal
DOI: 10.1016/j.bbrc.2013.11.114
关键词: MethamphetaminePotassium channelCalcium channelCardiotoxicityArrhythmias
英文摘要: Abstract(#br)Methamphetamine (MA) is a psychostimulant. MA may induce numerous cardiotoxic effects, leading to cardiac arrhythmias, heart failure, eventually leading to sudden cardiac death. The deleterious effects of methamphetamine work in tandem to disrupt the coordinated electrical activity of the heart and have been associated with life-threatening cardiac arrhythmias. Remodeling of ion channels is an important mechanism of arrhythmia. Although arrhythmogenic remodeling involves alterations in ion channel expression, it is yet unknown whether MA induced electrical remodeling by affecting gene expression, and whether the changes in protein expression are paralleled by alterations in mRNA expression. Our study focused on the expression of ion channels which were correlated to the...
全文获取路径: Elsevier  (合作)