The role of heat shock protein 90 in migration and proliferation of vascular smooth muscle cells in the development of atherosclerosis
作者: Jeonghan KimSung-Wuk JangEunsoo ParkMinseok OhSodam ParkJesang Ko
作者单位: 1Division of Life Sciences, Korea University, Seoul 136-701, South Korea
2Department of Medicine, Graduate School, University of Ulsan, Seoul 138-736, South Korea
刊名: Journal of Molecular and Cellular Cardiology, 2014, Vol.72 , pp.157-167
来源数据库: Elsevier Journal
DOI: 10.1016/j.yjmcc.2014.03.008
关键词: AtherosclerosisSmooth muscle cellHeat shock protein 90Restenosis
原始语种摘要: Abstract(#br)The molecular chaperone heat shock protein 90 (HSP90) is overexpressed in plaques of atherosclerosis patients, and is associated with plaque instability. However, the role of HSP90 in atherosclerosis remains unclear. The present study investigated the effects of HSP90 inhibition on migration and proliferation of vascular smooth muscle cells (VSMCs) and involvement in atherosclerosis. To examine the role of HSP90 in VSMC migration, VSMCs were treated with the specific HSP90 inhibitors, 17-N-allylamino-17-demethoxygeldanamycin (17-AAG) and STA-9090. Results of a chemotaxis assay showed that the HSP90 inhibitors suppress migration of VSMCs. HSP90 inhibition also prevented invasion and sprout formation of VSMCs via inhibition of matrix metalloproteinase-2 proteolytic activity....
全文获取路径: Elsevier  (合作)
影响因子:5.148 (2012)