Investigation of tyrphostin AG 556 for testicular torsion-induced ischemia reperfusion injury in rat
作者: Ersagun KaraguzelAbdullah SivrikayaAhmet MenteseEsin YulugSuha TurkmenOmer KutluYavuz GulerDiler UsSuleyman TurediAhmet AlverIlke O. Kazaz
作者单位: 1Department of Urology, Karadeniz Technical University, Faculty of Medicine, Trabzon 61080, Turkey
2Department of Medical Biochemistry, Karadeniz Technical University, Faculty of Medicine, Trabzon, Turkey
3Department of Histology and Embryology, Karadeniz Technical University, Faculty of Medicine, Trabzon, Turkey
4Department of Emergency Medicine, Karadeniz Technical University, Faculty of Medicine, Trabzon, Turkey
刊名: Journal of Pediatric Urology, 2014, Vol.10 (2), pp.223-229
来源数据库: Elsevier Journal
DOI: 10.1016/j.jpurol.2013.08.007
关键词: Tyrphostin Ag 556Ischemia reperfusion injuryTesticular torsionRat
英文摘要: Abstract(#br)Objective(#br)To investigate the effects of tyrphostin AG 556, a tyrosine kinase inhibitor (TKI) in an experimental model of testicular ischemia–reperfusion (I/R) injury.(#br)Material and methods(#br)Twenty-four adult male rats were randomly divided into four groups ( n = 6): sham, torsion/detorsion (T/D), T/D + dimethylsulfoxide (DMSO) (vehicle group), and T/D + DMSO + tyrphostin AG 556. Testicular torsion was achieved by rotating the left testis 720° clockwise for 4 h. Thirty minutes before detorsion, 3 mg/kg tyrphostin AG 556 was injected transperitoneally in the AG 556 group and DMSO was injected transperitoneally in the DMSO group. After 2 h of reperfusion arterial blood samples were collected for biochemical analysis for malondialdehyde (MDA), ischemia modified albumin...
全文获取路径: Elsevier  (合作)
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影响因子:1.368 (2012)

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