Simultaneous analysis of urinary phthalate metabolites of residents in Korea using isotope dilution gas chromatography–mass spectrometry
作者: Miok KimNa Rae SongJong-Ho ChoiJeongae LeeHeesoo Pyo
作者单位: 1Molecular Recognition Research Center, Korea Institute of Science and Technology, Hwarangno 14-gil 5, Seongbuk-gu, Seoul 136-791, Republic of Korea
2Department of Chemistry and Biochemistry, University of California, Los Angeles, 607 Charles E. Young Drive East Box 951569, Los Angeles, CA 90095-1569, USA
3Department of Chemistry, Korea University, 145, Anam-ro, Seongbuk-gu, Seoul, 136-701, Republic of Korea
刊名: Science of the Total Environment, 2014, Vol.470-471 , pp.1408-1413
来源数据库: Elsevier Journal
DOI: 10.1016/j.scitotenv.2013.07.037
关键词: Urinary phthalate metabolitesGas chromatography–mass spectrometryTrimethylsilylationIsotope dilutionBiomonitoring
原始语种摘要: Abstract(#br)Phthalates are used in industry products, household items, and medical tools as plasticizers. Human exposure to phthalates has raised concern about its toxicity. In the present study, optimization was conducted for the simultaneous analysis of eight kinds of phthalate metabolites using gas chromatography–mass spectrometry (GC-MS): MEP, MiBP, MnBP, MBzP, MiNP, MEHP, MEOHP, and MEHHP. In order to minimize the matrix effect and to do quantitative analysis, isotope dilution and LLE-GC-MS methods were performed. Urine samples were enzymatically hydrolyzed, extracted with a mixture of n -hexane and ethyl ether (8:2; v:v), and subsequently derivatized with trimethylsilylation. All eight kinds of analytes showed clear resolution and high reproducibility in GC-MS results. The method...
全文获取路径: Elsevier  (合作)
影响因子:3.258 (2012)