Adhesion patterns in the microvasculature are dependent on bifurcation angle
作者: Giuseppina LambertiFariborz SoroushAshley SmithMohammad F. KianiBalabhaskar PrabhakarpandianKapil Pant
作者单位: 1Department of Mechanical Engineering, Temple University, 1947 N. 12th Street, Philadelphia, PA 19122, USA
2Biomedical Technology, CFD Research Corporation, 701 McMillian Way, Huntsville, AL 35806, USA
3Department of Radiation Oncology, Temple University School of Medicine, 3500 N. Broad Street, Philadelphia, PA 19140, USA
刊名: Microvascular Research, 2015, Vol.99 , pp.19-25
来源数据库: Elsevier Journal
DOI: 10.1016/j.mvr.2015.02.004
关键词: BifurcationAdhesionFunctionalized particleNeutrophilMicrofluidic
原始语种摘要: Abstract(#br)Particle adhesion in vivo is highly dependent on the microvascular environment comprising of unique anatomical, geometrical, physiological fluid flow conditions and cell–particle and cell–cell interactions. Hence, proper design of vascular-targeted drug carriers that efficiently deliver therapeutics to the targeted cells or tissue at effective concentrations must account for these complex conditions observed in vivo. In this study, we build upon our previous results with the goal of characterizing the effects of bifurcations and their corresponding angle on adhesion of functionalized particles and neutrophils to activated endothelium. Our hypothesis is that adhesion is significantly affected by the type of biochemical interactions between particles and vessel wall as well as...
全文获取路径: Elsevier  (合作)
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影响因子:2.929 (2012)

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