3D hydrodynamics and shear rates’ variability in the United States Pharmacopeia Paddle Dissolution Apparatus
作者: Houari AmeurMohamed Bouzit
作者单位: 1Faculté de Génie Mécanique, USTO-MB, 1505 El m’naouar, Oran, Algeria
刊名: International Journal of Pharmaceutics, 2013, Vol.452 (1-2), pp.42-51
来源数据库: Elsevier Journal
DOI: 10.1016/j.ijpharm.2013.04.049
关键词: USP IIHydrodynamicsShear ratesComputational fluid dynamics (CFD)DissolutionModeling
原始语种摘要: Abstract(#br)The 3D hydrodynamics and shear rates distributions within the United States Pharmacopeia Apparatus 2 have been investigated in this paper. With the help of a CFD package, several geometric modifications to the device were evaluated in this study. Specially, we examine the influence of impeller clearance, blade diameter, shape of the vessel base and shape of the lower part of blade. Increasing the impeller clearance was observed to exacerbate the heterogeneity in shear and would likely result in greater variability in dissolution measurements. Use of moderate blade diameter and dished bottom were observed to reduce shear heterogeneity in the regions where tablets are most likely to visit during testing. The comparative analysis shows better reproducibility and accelerated...
全文获取路径: Elsevier  (合作)
影响因子:3.458 (2012)

  • observed 观察到的
  • shear 切变
  • likely 大概
  • rates 地方税
  • variability 变异性
  • bottom 底壁
  • lower 降下
  • examine 
  • several 各自
  • impeller 叶轮