Characterization of immunological responses in patients with severe fever with thrombocytopenia syndrome: A cohort study in China
作者: Qing-Bin LuNing CuiJian-Gong HuWei-Wei ChenWen XuHao LiXiao-Ai ZhangHinh LyWei LiuWu-Chun Cao
作者单位: 1School of Public Health, Peking University, Beijing 100191, PR China
2State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing 100071, PR China
3The 154 Hospital, People's Liberation Army, Xinyang 464000, PR China
4The 302 Hospital, People's Liberation Army, Beijing 100039, PR China
5University of Minnesota, Twin Cities, MN 55108, USA
刊名: Vaccine, 2015, Vol.33 (10), pp.1250-1255
来源数据库: Elsevier Journal
DOI: 10.1016/j.vaccine.2015.01.051
关键词: Severe fever with thrombocytopenia syndromeImmunological responseCohort studyHumoral immunity
原始语种摘要: Abstract(#br)Background(#br)The immunological responses of patients with severe fever with thrombocytopenia syndrome (SFTS) remain largely unknown. We aim to study the magnitude and sustainability of host immune responses and their correlation with clinical, virological and hematological parameters.(#br)Methods(#br)A longitudinal cohort study was performed in a SFTS reference hospital. The sequential immunological evaluation was determined for SFTSV infected patients, including anti-SFTSV IgM, IgG antibodies and the lymphocyte subsets.(#br)Results(#br)Altogether 298 laboratory-confirmed SFTS cases were analyzed, from whom 55 patients were followed after convalescence. SFTSV specific IgM antibody could be detected at medium of 9 days, surged to peak levels by 4 weeks, and remained...
全文获取路径: Elsevier  (合作)
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影响因子:3.492 (2012)

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