Anti-inflammatory effects of the hydroxycarboxylic acid receptor 2
作者: Emily C. GraffHan FangDesiree WandersRobert L. Judd
作者单位: 1Department of Anatomy, Physiology and Pharmacology, College of Veterinary Medicine, Auburn University, Auburn, AL, United States
2Department of Pathobiology, College of Veterinary Medicine, Auburn University, Auburn, AL, United States
3Department of Nutrition, Georgia State University, Atlanta, GA, United States
刊名: Metabolism, 2016, Vol.65 (2), pp.102-113
来源数据库: Elsevier Journal
DOI: 10.1016/j.metabol.2015.10.001
关键词: InflammationHCA 2GPR109aBeta-HydroxybutyrateNiacin
原始语种摘要: Abstract(#br)The hydroxycarboxylic acid receptors (HCA 1–3 ) are a family of G-protein-coupled receptors that are critical for sensing endogenous intermediates of metabolism. All three receptors are predominantly expressed on adipocytes and mediate anti-lipolytic effects. In addition to adipocytes, HCA 2 is highly expressed on immune cells, including macrophages, monocytes, neutrophils and dermal dendritic cells, among other cell types. The endogenous ligand for HCA 2 is beta-hydroxybutyrate (β-OHB), a ketone body produced by the liver through β-oxidation when an individual is in a negative energy balance. Recent studies demonstrate that HCA 2 mediates profound anti-inflammatory effects in a variety of tissues, indicating that HCA 2 may be an important therapeutic target for treating...
全文获取路径: Elsevier  (合作)
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影响因子:3.096 (2012)

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