Effects of aripiprazole and haloperidol on neural activation during the n-back in healthy individuals: A functional MRI study
作者: Rhianna GoozeeAntje A.T.S. ReindersRowena HandleyTiago MarquesHeather TaylorOwen O'DalyGrant McQueenKathryn HubbardValeria MondelliCarmine PariantePaola Dazzan
作者单位: 1Department of Psychosis Studies, Institute of Psychiatry, King's College London, UK
2Bristol-Myers Squibb, UK
3Centre for Neuroimaging Sciences (CNS), King's College London, UK
4Department of Psychological Medicine, Institute of Psychiatry, King's College London, UK
5NIHR Biomedical Research Centre for Mental Health at the South London and Maudsley NHS Foundation Trust, King's College London, London, UK
刊名: Schizophrenia Research, 2016, Vol.173 (3), pp.174-181
来源数据库: Elsevier Journal
DOI: 10.1016/j.schres.2015.02.023
关键词: SchizophreniaWorking memoryn-backFunctional neuroimagingAntipsychotic
原始语种摘要: Abstract(#br)Objective(#br)Antipsychotic drugs target neurotransmitter systems that play key roles in working memory. Therefore, they may be expected to modulate this cognitive function via their actions at receptors for these neurotransmitters. However, the precise effects of antipsychotic drugs on working memory function remain unclear. Most studies have been carried out in clinical populations, making it difficult to disentangle pharmacological effects from pathology-related brain activation. In this study, we aim to investigate the effects of two antipsychotic compounds on brain activation during working memory in healthy individuals. This would allow elucidation of the effects of current antipsychotic treatments on brain function, independently of either previous antipsychotic use or...
全文获取路径: Elsevier  (合作)
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影响因子:4.59 (2012)

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