Achieving ultrasensitive in vivo detection of bone crack with polydopamine-capsulated surface-enhanced Raman nanoparticle
作者: Chunhuan JiangYing WangJiawei WangWei SongLehui Lu
作者单位: 1State Key Laboratory of Electroanalytical Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, China
2University of Chinese Academy of Sciences, Beijing 100049, China
3State Key Laboratory of Supramolecular Structure and Materials, Jilin University, Changchun 130012, China
刊名: Biomaterials, 2017, Vol.114 , pp.54-61
来源数据库: Elsevier Journal
DOI: 10.1016/j.biomaterials.2016.11.007
关键词: Surface-enhanced Raman scatteringPolydopamineBone crackUltrasensitiveIn vivo detection
英文摘要: Abstract(#br)The timely diagnosis and intervention of bone microdamage are essential for preventing its accumulation and further diminishing the risk of skeletal fracture. Although staining methods have been adopted to better depict the microdamage on bone, their clinical impacts are still limited because they are based on histological sections which are inherently destructive. Here, highly sensitive and non-invasive in vivo detection of bone crack can be achieved by surface-enhanced Raman scattering (SERS) technique using a carefully chosen polydopamine (PDA)-SERS nanoparticle tag. The bone crack can be specifically labeled by PDA-SERS tags taking advantage of high affinity of PDA towards calcium exposed on the damaged bone, and identified by an intense featured Raman signal both in...
全文获取路径: Elsevier  (合作)
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影响因子:7.604 (2012)

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