Effects of antiretroviral treatment on paraoxonase 1 (PON1) activity in rats
作者: Jolanta Elżbieta PastrykMarta RusekJerzy Bełtowski
作者单位: 1Department of Pathophysiology, Medical University of Lublin, 8b Jaczewskiego Street, 20-090 Lublin, Poland
刊名: Chemico-Biological Interactions, 2016, Vol.259 , pp.407-412
来源数据库: Elsevier Journal
DOI: 10.1016/j.cbi.2016.06.031
关键词: ParaoxonaseAntiretroviral therapyProtease inhibitorsDyslipidemiaAtherosclerosis
英文摘要: Abstract(#br)Highly active antiretroviral therapy (HAART), especially protease inhibitors (PIs), commonly used in HIV-infected patients, effectively suppresses a viral replication. However, it is frequently associated with significant side effects, including fat redistribution, lipodystrophy, hyperlipidemia, insulin resistance and diabetes mellitus. Currently, metabolic complications and atherosclerosis resulting from them become the major cause of mortality in HIV-infected patients receiving HAART. Paraoxonase 1 (PON1) is the HDL-bound esterase, which inhibits development of atherosclerosis by decomposing lipid peroxidation products and hydrolyzing homocysteine thiolactone.(#br)The aim of this study was to characterize the effects of HIV protease inhibitors on PON1 activity, total plasma...
全文获取路径: Elsevier  (合作)
影响因子:2.967 (2012)