The effect of ethyl pyruvate and N -acetylcysteine on ischemia-reperfusion injury in an experimental model of ischemic stroke
作者: Suha TurkmenOzgen Cekic GonencYunus KaracaAhmet MenteseSelim DemirErcument BeyhunAynur SahinAbdulkadir GunduzEsin YulugSuleyman Turedi
作者单位: 1Department of Emergency Medicine, Faculty of Medicine, Karadeniz Technical University, Trabzon, Turkey
2Department of Biochemistry, Faculty of Medicine, Karadeniz Technical University, Trabzon, Turkey
3Department of Public Health, Faculty of Medicine, Karadeniz Technical University, Trabzon, Turkey
4Department of Histology, Faculty of Medicine, Karadeniz Technical University, Trabzon, Turkey
刊名: American Journal of Emergency Medicine, 2016, Vol.34 (9), pp.1804-1807
来源数据库: Elsevier Journal
DOI: 10.1016/j.ajem.2016.06.003
英文摘要: Abstract(#br)Introduction(#br)Reperfusion therapies play an important role in early-period treatment for patients presenting to the emergency department due to stroke. However, the ischemia-reperfusion injury that may occur with reperfusion must then be considered. The purpose of this study was to determine the effectiveness of N -acetylcysteine (NAC) and ethyl pyruvate in preventing ischemia-reperfusion injury.(#br)Method(#br)This study is a randomized, controlled experimental study. In group 1, rats' left main carotid arteries were clamped. Reperfusion was established by releasing the clamp after 1.5 hours. In group 2, the left main carotid artery was clamped, and 20 mg/kg intraperitoneal NAC was administered after 1 hour. The clamp was released 0.5 hour after NAC administration. In...
全文获取路径: Elsevier  (合作)
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影响因子:1.704 (2012)

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