Renal vasculature reactivity to agonist of P2X7 receptor is increased in streptozotocin-induced diabetes
作者: Ewelina KreftRobert KowalskiMaciej JankowskiMirosława Szczepańska-Konkel
作者单位: 1Department of Therapy Monitoring and Pharmacogenetics, Medical University of Gdańsk, Gdańsk, Poland
2Department of Clinical Chemistry, Medical University of Gdańsk, Gdańsk, Poland
3Laboratory of Molecular and Cellular Nephrology, Mossakowski Medical Research Centre, Polish Academy of Science, Gdańsk, Poland
刊名: Pharmacological Reports, 2016, Vol.68 (1), pp.71-74
来源数据库: Elsevier Journal
DOI: 10.1016/j.pharep.2015.06.140
关键词: ATPDiabetesKidneyNephropathyP2X7 receptor
原始语种摘要: Abstract(#br)Background(#br)Diabetic nephropathy is characterized by the dysfunction of renal microvasculature. The involvement of the P2X7 receptor, being a part of the purinergic system, is presumable in this process. The aim of our study was to investigate the P2X7 receptor-mediated renal microvasculature response and renal metabolism of extracellular adenine nucleotides in diabetic rats.(#br)Methods(#br)Study was performed on streptozotocin-induced diabetic Wistar rats. The vascular response to BzATP, an agonist of the P2X7 receptor, was monitored based on the changes of cortical blood flow (CBF), glomerular filtration rate (GFR) and glomerular inulin space (GIS). The renal interstitial fluid (RIF) was probed by microdialysis technique and concentrations of ATP and adenosine were...
全文获取路径: Elsevier  (合作)
影响因子:1.965 (2012)

  • streptozotocin 链脲佐菌素
  • receptor 接受体
  • diabetes 糖尿病
  • increased 增加
  • induced 感应的
  • reactivity 反应性
  • nephropathy 肾病
  • diabetic 糖尿病患者
  • glomerular 肾小球病
  • renal 肾的