Relation between serum prolactin levels and antipsychotic response to risperidone in patients with schizophrenia
作者: Alladi CharanDeepak Gopal ShewadeRavi Philip RajkumarAdithan Chandrasekaran
作者单位: 1Department of Pharmacology, JIPMER, Puducherry 605006, India
2Department of Psychiatry, JIPMER, Puducherry 605006, India
3Department Of Clinical Pharmacology, JIPMER, Puducherry 605006, India
刊名: Psychiatry Research, 2016, Vol.240 , pp.209-213
来源数据库: Elsevier Journal
DOI: 10.1016/j.psychres.2016.04.001
关键词: Dopamine receptor (DRD2)DRD2 Taq1A polymorphismSchizophreniaProlactinPANSS (Positive and Negative Syndrome Scale)
原始语种摘要: Abstract(#br)Background(#br)Hyperprolactinemia is commonly seen in patients with schizophrenia on risperidone. Dopamine receptor blockade plays a major role in risperidone induced hyperprolactinemia. However, limited studies are available with inconsistent results on antipsychotic response to risperidone and prolactin elevation. Therefore, we aimed to study the change in serum prolactin levels and response to risperidone and to test the association between DRD2 genetic variants and prolactin levels in schizophrenic patients treated with risperidone.(#br)Methods(#br)A prospective study comprising of 102 patients with schizophrenia were recruited. Prolactin levels and Positive and Negative Syndrome Scale (PANSS) score were recorded at baseline and after four weeks of risperidone treatment....
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影响因子:2.456 (2012)

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