A 50-Hz magnetic-field exposure promotes human amniotic cells proliferation via SphK–S1P–S1PR cascade mediated ERK signaling pathway
50 Hz磁场暴露通过SphK-S1P-S1PR级联介导的ERK信号通路促进人羊膜细胞增殖
作者: Liangjing ChenYongpeng XiaJingchun LuQixin XieAnfang YeWenjun Sun
作者单位: 1Bioelectromagnetics Key Laboratory, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China
2Department of Occupational Disease of the First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China
3Institute of Environmental Medicine, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China
刊名: Ecotoxicology and Environmental Safety, 2020, Vol.194
来源数据库: Elsevier Journal
DOI: 10.1016/j.ecoenv.2020.110407
关键词: 50-Hz magnetic-field (MF) exposureSphingosine kinase 1 (SphK1)Sphingosine-1-phosphate (S1P)Extracellular signal-regulated kinase (ERK)Proliferation
英文摘要: Abstract(#br)Extremely low-frequency electromagnetic fields (ELF-EMFs) present a kind of common non-ionizing radiation in public and occupational environments. Previous studies have suggested that ELF-EMF exposure might have a potential impact on co-carcinogenesis and the progression of tumorigenesis by inducing cell proliferation. However, the underlying mechanisms remain largely unknown. In this study, we investigated the possible role of the sphingosine-1-phosphate (S1P)-related pathway in regulating cell proliferation induced by 50-Hz, 0.4-mT magnetic-field (MF) exposure. The results showed that MF exposure significantly promoted sphingosine kinase 1 (SphK1) activity, and that inhibition of the SphK1 – S1P – S1P receptor (S1PR) pathway could remarkably reverse MF-induced cell...
全文获取路径: Elsevier  (合作)
影响因子:2.203 (2012)

  • amniotic 羊膜的
  • cascade 小瀑布
  • pathway 轨道
  • exposure 暴露
  • cells 麻风细胞
  • proliferation 增生
  • signaling 发信号
  • human 人的
  • magnetic 磁的
  • field