Data on Tougu Xiaotong capsules may inhibit p38 MAPK pathway-mediated inflammation in vitro
有关透骨消痛胶囊的数据可能在体外抑制p38 MAPK通路介导的炎症反应
作者: Xihai LiZhenli ZhangWenna LiangJianwei ZengXiang ShaoLimei XuLiangliang JiaXiaojuan HeHui LiChunsong ZhengHongzhi YeTetsuya Asakawa
作者单位: 1Academy of Integrative Medicine, Fujian University of Traditional Chinese Medicine, Fuzhou, 350122, PR China
2Fujian Key Laboratory of Integrative Medicine on Geriatrics, Fuzhou 350122, PR China
3SIPO Patent Examination (Beijing) Center, Beijing 100160, PR China
4Research Base of Traditional Chinese Medicine Syndrome, Fujian University of Traditional Chinese Medicine, Fuzhou 350122, China
5Department of Neurosurgery, Hamamatsu University School of Medicine, Handayama, 1-20-1, Higashi-ku, Hamamatsu-city, Shizuoka 431-3192, Japan
刊名: Data in Brief, 2020, Vol.28
来源数据库: Elsevier Journal
DOI: 10.1016/j.dib.2019.105023
关键词: OsteoarthritisTougu Xiaotong capsuleInflammationChondrocyteToll like receptor 4
英文摘要: Abstract(#br)The Tougu Xiaotong capsule (TXC) is a traditional herbal compound used to treat osteoarthritis (OA) in China. We performed fingerprint analysis with HPLC for the quality control of TXC. Its composition was identified by the comparison of the spectrogram and chromatographic peak of retention time with a reference substance. TXC was found to contain paeoniflorin, isofraxidin, ferulic acid, and rosmarinic acid. The chondrocytes were identified by immunohistochemical staining using collagen II. Chondrocytes that were positive for collagen II were stained brown in the cytoplasm. The toll-like receptor 4 (TLR4) was expressed on the chondrocyte membrane, which was observed using immunofluorescence microscopy. The nuclei were stained blue by 4′,6-diamidino-2-phenylindole (DAPI) and...
全文获取路径: Elsevier  (合作)
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关键词翻译
关键词翻译
  • inflammation 炎症
  • capsules 微囊农药
  • pathway 轨道
  • inhibit 禁止
  • vitro 体外
  • Data 数据