High ratio of ω-3/ω-6 polyunsaturated fatty acids targets mTORC1 to prevent high-fat diet-induced metabolic syndrome and mitochondrial dysfunction in mice
高比例的ω-3 / ω-6多不饱和脂肪酸靶向mTORC1,预防高脂饮食诱导的小鼠代谢综合征和线粒体功能障碍
作者: Run LiuLei ChenYan WangGuanfei ZhangYing ChengZhihui FengXiaochun BaiJiankang Liu
作者单位: 1Center for Mitochondrial Biology and Medicine, The Key Laboratory of Biomedical Information Engineering of Ministry of Education, School of Life Science and Technology, Xi'an Jiaotong University, 710049, China
2Department of Cell Biology, School of Basic Medical Sciences, Southern Medical University, Guangzhou, China
刊名: The Journal of Nutritional Biochemistry, 2020, Vol.79
来源数据库: Elsevier Journal
DOI: 10.1016/j.jnutbio.2019.108330
关键词: Ω-3 PUFAsMTORC1Mitochondrial functionMetabolic syndromeTCA cycle
英文摘要: Abstract(#br)Adjusting ω-3/ω-6 polyunsaturated fatty acids (PUFAs) ratio in high-fat diet is one potential mean to improve metabolic syndrome; however, underlying mechanisms remain unclear. Four groups of mice were fed 60% kcal diets with saturated fatty acids, three different ω-3/ω-6 PUFAs ratios (low, middle and high) for 12 weeks, respectively. Body weight, atherosclerosis marker, insulin signal index and level of lipid accumulation in liver were significantly lowered in High group compared with saturated fatty acids group and Low group at week 12. Expressions of p-mTOR and raptor were inhibited by high ω-3 PUFAs. Importantly, ω-3 PUFAs intake up-regulated mitochondrial electron transport chain and tricarboxylic acid cycle pathway through metabolomics analysis in liver. Mitochondrial...
全文获取路径: Elsevier  (合作)
影响因子:4.552 (2012)

  • induced 感应的
  • prevent 避免
  • metabolic 新陈代谢的
  • mitochondrial 线粒体的
  • dysfunction 功能障碍
  • fatty 脂肪的
  • syndrome 症候群
  • TCA TeleCommunications Association
  • ratio 
  • cycle 旋回