CT2-3, a novel magnolol analogue suppresses NSCLC cells through triggering cell cycle arrest and apoptosis
作者: Jian ChenCheng TaoXiaofei HuangZide ChenLi WangXinping LiMin MaZhengzhi Wu
作者单位: 1Integrated Chinese and Western Medicine Postdoctoral Research Station, Jinan University, Guangzhou 510632, China
2The First Affiliated Hospital of Shenzhen University, Shenzhen Second People's Hospital, Shenzhen 518035, China
3Shenzhen Institute of Geriatrics, Shenzhen 518020, China
4Research Center of Integrative Medicine, School of Basic Medical Sciences, Guangzhou University of Chinese Medicine, Guangzhou 510006, China
5Department of Cardiovascular Medicine, The First Affiliated Hospital of Henan University of Chinese Medicine, Zhengzhou 450000, China
6College of Traditional Chinese Medicine, Jinan University, Guangzhou 510632, China
7The First Affiliated Hospital of Jinan University, Guangzhou 510630, China
8The Eighth Affiliated Hospital of Sun Yat-sen University, Shenzhen 518033, China
刊名: Bioorganic & Medicinal Chemistry, 2020, Vol.28 (6)
来源数据库: Elsevier Journal
DOI: 10.1016/j.bmc.2020.115352
关键词: MagnololAnalogueNSCLCROSApoptosis
原始语种摘要: Abstract(#br)Magnolol, a major bioactive component found in Magnolia officinalis with anti-inflammation and anti-oxidation activities as well as minimized cytotoxic effects. Although magnolol has a wide range of clinical applications, the anti-tumor activity of magnolol is not efficient. Herein, we reported the synthesis and anti-cancer activities of three novel magnolol analogues CT2-1, CT2-2, CT2-3, among which CT2-3 revealed more efficient anti-non-small cell lung cancer (NSCLC) activity than magnolol. Our data showed that CT2-3 could significantly inhibit the proliferation of human NSCLC cells in a dose-dependent manner. In addition, we revealed CT2-3 could induce cell cycle arrest through down-regulating mRNA expression of CDK4, CDK6 and cyclin D1. Moreover, we verified that CT2-3...
全文获取路径: Elsevier  (合作)
影响因子:2.903 (2012)

  • analogue 相似体
  • magnolol 木兰醇
  • arrest 制动器
  • novel 长篇小说
  • apoptosis 细胞死
  • triggering 起动
  • cells 麻风细胞
  • cycle 旋回
  • ROS Read Only Storage
  • through 经过