Fibrosis and cancer: A strained relationship
作者: Bram PiersmaM.K. HaywardValerie M. Weaver
作者单位: 1Department of Surgery and Center for Bioengineering and Tissue Regeneration, University of California, San Francisco (UCSF), USA
2Matrix research group, Department of Pathology and Medical Biology, University Medical Center Groningen, University of Groningen, the Netherlands
3Departments of Radiation Oncology, Bioengineering and Therapeutic Sciences, Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research at UCSF, UCSF Helen Diller Comprehensive Cancer Center, 513 Parnassus Avenue, HSE565, San Francisco, CA 94143-0456, USA
刊名: BBA - Reviews on Cancer, 2020, Vol.1873 (2)
来源数据库: Elsevier Journal
DOI: 10.1016/j.bbcan.2020.188356
关键词: MechanoreciprocityCancerECMCAFFibrosis
英文摘要: Abstract(#br)Tumors are characterized by extracellular matrix (ECM) deposition, remodeling, and cross-linking that drive fibrosis to stiffen the stroma and promote malignancy. The stiffened stroma enhances tumor cell growth, survival and migration and drives a mesenchymal transition. A stiff ECM also induces angiogenesis, hypoxia and compromises anti-tumor immunity. Not surprisingly, tumor aggression and poor patient prognosis correlate with degree of tissue fibrosis and level of stromal stiffness. In this review, we discuss the reciprocal interplay between tumor cells, cancer associated fibroblasts (CAF), immune cells and ECM stiffness in malignant transformation and cancer aggression. We discuss CAF heterogeneity and describe its impact on tumor development and aggression focusing on...
全文获取路径: Elsevier  (合作)

  • relationship 关系
  • CAF Calibration Flight
  • ECM Effective Complex Modules
  • strained 受力
  • Cancer 巨蟹座
  • cancer 癌症