MANF delivery improves retinal homeostasis and cell replacement therapies in ageing mice
作者: Joana NevesKathleen R. ChircoWendy Cedron-CraftShereen ChewJie ZhuHeinrich JasperDeepak A. Lamba
作者单位: 1Paul F. Glenn Center for Biology of Aging Research, Buck Institute for Research on Aging, 8001 Redwood Boulevard, Novato, CA 94945-1400, USA
2Instituto de Medicina Molecular (iMM), Faculdade de Medicina, Universidade de Lisboa, Lisbon 1649-028, Portugal
3The Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, Department of Ophthalmology, University of California, San Francisco, SF, USA
4Immunology Discovery, Genentech, Inc., 1 DNA Way, South San Francisco, CA 94080, USA
刊名: Experimental Gerontology, 2020, Vol.134
来源数据库: Elsevier Journal
DOI: 10.1016/j.exger.2020.110893
原始语种摘要: Abstract(#br)Ageing is a major risk factor for vision loss, and inflammation is an important contributor to retinal disease in the elderly. Regenerative medicine based on cell replacement strategies has emerged in recent years as a promising approach to restore vision. However, how the ageing process affects retinal homeostasis and inflammation in the retina and how this may impose a limitation to the success of such interventions remains unknown. Here we report that, in mice and humans, retinal ageing is associated with a reduction in MANF protein levels, specifically in the choroid, where increased densities of activated macrophages can be detected. We further show that the retina of old wild type mice, in the absence of any other genetic alteration, has limited homeostatic capacity...
全文获取路径: Elsevier  (合作)
影响因子:3.911 (2012)

  • retinal 视黄醛
  • homeostasis 体内平衡
  • replacement 交代
  • ageing 老化
  • delivery 移交