Highly selective and sensitive online measurement of trace exhaled HCN by acetone-assisted negative photoionization time-of-flight mass spectrometry with in-source CID
作者: Yuanyuan XieQingyun LiLei HuaPing ChenFan HuNingbo WanHaiyang Li
作者单位: 1Key Laboratory of Separation Science for Analytical Chemistry, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, 457 Zhongshan Road, Dalian, Liaoning, 116023, People’s Republic of China
2University of Chinese Academy of Sciences, 19 Yuquan Road, Beijing, 100049, People’s Republic of China
3Henan Province Medical Instrument Testing Institute, 79 Xiongerhe Road, Zhengzhou, 450018, People’s Republic of China
刊名: Analytica Chimica Acta, 2020, Vol.1111 , pp.31-39
来源数据库: Elsevier Journal
DOI: 10.1016/j.aca.2020.03.035
关键词: Acetone-assisted negative photoionizationIn-source collision-induced dissociationHydrogen cyanideTime-of-flight mass spectrometryCystic fibrosisPseudomonas aeruginosa
英文摘要: Abstract(#br)Exhaled hydrogen cyanide (HCN) has been extensively investigated as a promising biomarker of the presence of Pseudomonas aeruginosa in the airways of patients with cystic fibrosis (CF) disease. Its concentration profile for exhalation can provide useful information for medical disease diagnosis and therapeutic procedures. However, the complexity of breath gas, like high humidity, carbon dioxide (CO 2 ) and trace organic compounds, usually leads to quantitative error, poor selectivity and sensitivity for HCN with some of existing analytical techniques. In this work, acetone-assisted negative photoionization (AANP) based on a vacuum ultraviolet (VUV) lamp with a time-of- flight mass spectrometer (AANP-TOFMS) was firstly proposed for online measurement of trace HCN in human...
全文获取路径: Elsevier  (合作)
影响因子:4.387 (2012)

  • acetone 丙酮
  • measurement 测量
  • selective 选择性的
  • spectrometry 光谱测定
  • flight 飞行
  • assisted 辅助的
  • trace 痕迹
  • CID Channel Identification
  • sensitive 灵敏的
  • online 联机