Role of gene polymorphisms related to progesterone elevation in women undergoing long GnRH agonist protocols
作者: Ping CaoBenyu MiaoYan XuQi FanQian ZhangGuirong ZhangCanquan ZhouYanwen Xu
作者单位: 1The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China
2Guangdong Provincial Key Laboratory of Reproductive Medicine, Guangzhou, China
3Peking Medriv Academy of Genetics and Reproduction, Peking, China
刊名: Reproductive BioMedicine Online, 2020, Vol.40 (3), pp.381-392
来源数据库: Elsevier Journal
DOI: 10.1016/j.rbmo.2019.12.013
关键词: GnRH agonist long protocolProgesteroneSingle-nucleotide polymorphism
原始语种摘要: ABSTRACT(#br)Research question(#br)Can single-nucleotide polymorphisms (SNP) of genes related to progesterone synthesis predict the risk of premature serum progesterone elevation in women undergoing gonadotrophin-releasing hormone agonist protocols for ovarian stimulation?(#br)Design(#br)A total of 765 women were divided into high progesterone and normal progesterone groups according to progesterone concentration on the day of human chorionic gonadotrophin (HCG) administration, with the 75th percentile as the threshold between the group. Associations were analysed of genetic information from whole exome sequencing and the clinical characteristics of the two groups to identify the relationship between SNP, haplotypes and serum progesterone elevation.(#br)Results(#br)Among 40 common SNP of...
全文获取路径: Elsevier  (合作)
影响因子:2.675 (2012)

  • progesterone 孕酮
  • nucleotide 核苷酸
  • elevation 隆起
  • related 有关的
  • GnRH 促性腺[激]素释放激素
  • haplotype 单倍体型
  • gonadotrophin 促性腺激素
  • agonist 织肌
  • sequencing 排序
  • FDR Facility Data Report