Redox activation of excitatory pathways in auditory neurons as mechanism of age-related hearing loss
氧化还原激活听觉神经元内兴奋通路作为年龄相关听力损失的机制
作者: Francis RoussetGerman Nacher-SolerMarta CoelhoSten IlmjarvVivianne Beatrix Christina KokjeAntoine MarteynYves CambetMichael PernyMarta RoccioVincent JaquetPascal SennKarl Heinz Krause
作者单位: 1Hearing and Olfaction Research Laboratory, Department of Pathology and Immunology, Faculty of Medicine, University of Geneva, Switzerland
2Department of Pathology and Immunology, Faculty of Medicine, University of Geneva, Switzerland
3READS Unit, Faculty of Medicine, University of Geneva, Switzerland
4Department of Biomedical Research (DBMR), University of Bern, Switzerland
5Department of Otorhinolaryngology, Inselspital Bern, Switzerland
6Department of Clinical Neurosciences, Service of ORL & Head and Neck Surgery, University Hospital of Geneva, Switzerland
刊名: Redox Biology, 2020, Vol.30
来源数据库: Elsevier Journal
DOI: 10.1016/j.redox.2020.101434
关键词: NADPH oxidaseAge-related hearing lossPresbycusisGlutamatergic signalingAuditory neuronsExcitotoxicity
英文摘要: Abstract(#br)Age-related hearing (ARHL) loss affects a large part of the human population with a major impact on our aging societies. Yet, underlying mechanisms are not understood, and no validated therapy or prevention exists. NADPH oxidases (NOX), are important sources of reactive oxygen species (ROS) in the cochlea and might therefore be involved in the pathogenesis of ARHL. Here we investigate ARHL in a mouse model. Wild type mice showed early loss of hearing and cochlear integrity, while animals deficient in the NOX subunit p22 phox remained unaffected up to six months. Genes of the excitatory pathway were down-regulated in p22 phox -deficient auditory neurons. Our results demonstrate that NOX activity leads to upregulation of genes of the excitatory pathway, to excitotoxic cochlear...
全文获取路径: Elsevier  (合作)
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关键词翻译
关键词翻译
  • auditory 听觉的
  • hearing 听觉
  • excitatory 刺激性的
  • mechanism 机构
  • activation 活化
  • related 有关的